邱 玲
编辑: 化学与材料工程学院   来源:   发布日期:2017-03-08  

 

一、个人简介

邱玲,女,19801月出生,研究员,江南大学兼职硕士生导师,江苏省原子医学研究所药物设计研究室主任。

 

二、研究方向

创新药物的设计、合成及其应用基础研究

 

三、学术成果 

1、主持的科研项目

[1]      第五期省“333工程人才培养项目“新型肿瘤靶向光动力诊疗药物的研究”(批准号:BRA20165182017.1~2018.12

[2]      江苏省“十三五科教强卫工程”青年医学重点人才项目骨靶向纳米光动力诊疗剂的研制(批准号:QNRC20166262016.1~2020.12

[3]      江苏省“十二五科教兴卫工程”医学重点人才项目新型铂-唑来膦酸类骨靶向抗癌药物的研制(批准号:RC20110972011.1~2015.12

[4]      江苏省自然科学基金新型铂-唑来膦酸类配合物的设计合成及生物活性研究(批准号:BK201411022014.7~2017.6

[5]      江苏省自然科学基金新型唑来膦酸类化合物的设计、合成及抗肿瘤活性研究(批准号:BK20090772009.12~2012.12

[6]      国家自然科学基金“99mTc标记双膦酸盐类骨肿瘤诊治剂的计算机辅助设计与合成(批准号:208010242009.1~2011.12

[7]      吴阶平医学基金会临床科研专项资助基金新型骨肿瘤诊治剂的计算机辅助设计及其合成与活性研究(批准号:320.6750.080562009.1~2011.12

 

2、代表性论文

[1]    Ling Qiu, Jianguo Lin, Edward J. Bertaccini. Insights into the Nature of Anesthetic-Protein Interactions: An ONIOM Study. Journal of Physical Chemistry B 2015, 119, 12771-12782.

[2]    Ling Qiu, Gaochao Lv, Liubin Guo, Liping Chen, Shineng Luo, Meifen Zou, Jianguo Lin*. Synthesis, crystal structure and antitumor effect of a novel copper(II) complex bearing zoledronic acid derivative. European Journal of Medicinal Chemistry 2015, 89, 42-50.

[3]    Ling Qiu, Gaochao Lv, Yang Cao, Liping Chen, Hui Yang, Shineng Luo,* Meifen Zou, Jianguo Lin*. Synthesis and biological evaluation of novel platinum complexes of imidazolyl -containing bisphosphonates as potential anticancer agents. Journal of Biological Inorganic Chemistry 2015, 20:1263-1275.

[4]    Ling Qiu, Qingzhu Liu, Yang Wang, Tengfei Wang, Hui Yang, Xuehai Ju, Shineng Luo, Jianguo Lin*. DFT Investigations on the Structure and Properties of MBP Dimers and Crystal with Strong Hydrogen-Bonding Interactions. Structural Chemistry 2015, 26, 845-858.

[5]    Ling Qiu, Jianguo Lin*, Liqing Wang, Wen Cheng, Yang Cao, Xuewen Liu, and Shineng Luo. A Series of Imidazolyl-Containing Bisphosphonates with Abundant Hydrogen-Bonding Interactions: Syntheses, Structures and Bone-Binding Affinity. Australian Journal of Chemistry 2014, 67, 192-205.

[6]    Ling Qiu, Jianguo Lin*, Wen Cheng, Yan Wang, Shineng Luo. 99mTc-labeled butyl-substituted zoledronic acid as a novel potential SPECT imaging agent: preparation and preclinical pharmacology study. Medicinal Chemistry Research 2013, 22: 6154-6162.

[7]    Ling Qiu, Wen Cheng, Jianguo Lin*, Liping Chen, Jun Yao, Wenwen Pu, Shineng Luo*. Synthesis and evaluation of a series of 99mTc-labelled zoledronic acid derivatives as potential bone seeking agent. Journal of Radioanalytical and Nuclear Chemistry 2013, 295, 545-552.

[8]    Ling Qiu, Jianguo Lin*, Shineng Luo, Yan Wang, Wen Cheng, Shu Zhang. A Novel 99mTc-Labeled Dimethyl-Substituted Zoledronic Acid (DMIDP) with Improved Bone Imaging Efficiency. Radiochimica Acta 2012, 100, 463-472.

[9]    Ling Qiu, Wen Cheng, Jianguo Lin*, Liping Chen, Jun Yao, Shineng Luo. Synthesis and biological evaluation of a series of 99mTc-labeled disphosphonates as novel radiotracers with improved bone imaging. Journal of Labelled Compounds and Radiopharmaceuticals 2012, 55, 429-435.

[10]Ling Qiu, Wen Cheng, Jianguo Lin, Shineng Luo, Li Xue, Jing Pan. Synthesis and Biological Evaluation of Novel 99mTc-Labelled Bisphosphonates for Superior Bone Imaging Agent. Molecules, 2011, 16, 6165-6178.

[11]Gaochao Lv, Ling Qiu*, Guiqing Liu; Wei Wang; Ke Li; Xueyu Zhao; Jianguo Lin*. Ph sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effects. Dalton Transactions 2016, 45,18147–18155

[12]Liubin Guo, Gaochao Lv, Ling Qiu*, Hui Yang, Li Zhang, Huixin Yu, Meifen Zou and Jianguo Lin*. Insights into anticancer activity and mechanism of action of a ruthenium(II) complex in human esophageal squamous carcinoma EC109 cells. European Journal of Pharmacology 2016, 786, 60-71.

[13]Qingzhu Liu, Ling Qiu,* Yang Wang, Gaochao Lv, Guiqing Liu, Shanshan Wang, Jianguo Lin*. Solvent effect on molecular structure, IR spectra, thermodynamic properties and chemical stability of zoledronic acid: DFT study. Journal of Molecular Modeling, 2016, 22(4):1-11

[14]Gaochao Lv, Liubin Guo, Ling Qiu*, Hui Yang, Tengfei Wang, Hong Liu, Jianguo Lin*Lipophilicity-dependent ruthenium N-heterocyclic carbene complexes as potential anticancer agents, Dalton Transactions, 2015, 44, 7324-7331.

[15]Yang Wang, Qingzhu Liu, Ling Qiu*, Tengfei Wang, Haoliang Yuan, Jianguo Lin, Shineng Luo*. Molecular structure, IR spectra, and chemical reactivity of Cisplatin and Transplatin: DFT studies, basis set effect and solvent effect. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 150, 902-908.

[16]Jianguo Lin, Ling Qiu*, Wen Cheng, Shineng Luo, Wanzhong Ye. Preparation and in vivo biological investigations on a novel radioligand for bone scanning: Technetium-99m labeled zoledronic acid derivative. Nuclear Medicine and Biology 2011, 38, 619-629.

 

3、已授权专利

1、邱玲,林建国,程文,罗世能,王燕,叶万忠。一种亲骨性99mTc-IPrDP配合物、其制备方法及其应用,中国发明专利号:ZL201010216218.2      

2、邱玲,林建国,陈丽萍,罗世能,程文, 姚君。一种双核铂(II-双膦酸类配合物及其制备方法和应用,中国发明专利号:ZL201210242328.5

3、邱玲,林建国,陈丽萍,罗世能,程文,曹阳。一种双膦酸铜配合物、其,制备方法及制药用途,中国发明专利号:ZL201210372131.3

4、林建国,邱玲,程文,罗世能。一种含2-乙基咪唑的双膦酸化合物及其制备方法和应用,中国发明专利号:ZL201210042920.0

5、林建国,邱玲,陈丽萍,罗世能,程文。一种双核铂(Ⅱ)–唑来膦酸配合物及其制备和应用,中国发明专利号:ZL201210061319.6

6、邱玲,林建国,刘学文,程文。一种液体分离仪器及液体分离装置,中国实用新型专利号:ZL201220651394.3

7、邱玲,林建国,程文,刘学文。一种液体分离仪器及液体分离装置,中国实用新型专利号:ZL201220651473.4

8、邱玲,林建国,吕高超,袁浩亮,郭刘斌。一种防爆沸蒸馏装置,中国实用新型专利号:ZL201420373294.8

9、邱玲,林建国,吕高超,郭刘斌,袁浩亮。一种用于负压环境下的防爆沸蒸馏装置,中国实用新型专利号:ZL201420373794.1

 

4、获奖情况

1、江苏省卫生厅医学新技术引进奖一等奖,核素标记唑来膦酸盐类药物的关键技术及其在骨显像中的应用(排名第一)

2、2016年度全国商业科技进步奖三等奖,第三代双膦酸及其金属螯合物在肿瘤及其骨转移诊疗中的应用研究(排名第一)

3、2014年度江苏医学科技奖三等奖,99m锝标记唑来膦酸盐类分子探针用于骨骼疾病靶向诊治作用的研究(排名第一)

4、2014年度全国商业科技进步奖一等奖,双膦酸盐用于骨骼肿瘤诊断和治疗的研究及产业化(排名第五)

 

四、联系方式

通讯地址:江苏省原子医学研究所,无锡市钱荣路20号,214063

Email: qiuling@jsinm.org

 

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